Nephrotic syndrome
Conditions
Interventions
SSNS vs. SDNS/FRNS:Nil
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: The starting time of the cohort is from January 1, 2020 to December 31, 2021. Patients can withdraw from the study at any time. The patients included in the study must meet the following conditions: 1. Patients with onset age from 1 to 18 years old and followed up continuously for more than 1 year in our hospital; 2. Visit time: the patient will go to see a doctor from January 1, 2018 to December 31, 2019, and register in children's Hospital Affiliated to Chongqing Medical University or PNS platform. 3. Diagnostic criteria of primary nephrotic syndrome (PNS): massive proteinuria: 24h proteinuria >= 50mg / kg or morning urine protein / creatinine (mg / mg) >= 2.0, three times a week morning urine protein qualitative (+ + + - + + + +); hypoproteinemia: serum albumin lower than 25g / L; hyperlipidemia: serum cholesterol higher than 5.7mmol/l; edema of different degrees. In the above 4 items, 1 and 2 were the necessary conditions for diagnosis; 4. Different types of hormone response criteria: (1) SSNs: prednisone 2 mg / (kg. D) or 60 mg / (m2. D) was used to treat the patients whose urine protein turned negative within 4 weeks, and those who were followed up for more than 2 years without recurrence. (2) SDNS / FRNs: those who are sensitive to hormone, but relapse within 2 weeks after two successive dose reduction or withdrawal, and at the same time meet the requirements of recurrence >= 2 times in half a year or more than 4 times in 1 year. SSNs should exclude late-onset SRNS during follow-up.
Exclusion criteria
Exclusion criteria: 1. Excluding patients with chronic kidney disease caused by secondary nephrotic syndrome (allergic purpura, lupus, hepatitis B, diabetes, hereditary nephritis, severe infection, tumor, drug); 2. Excluding patients with obvious side effects of hormone, unable to tolerate hormone or having hormone contraindication; 3. Except nephritic nephrotic syndrome (NNs), which has one or more of the following four items: (1) Within 2 weeks, 3 times of centrifugation urine microscopy was used to detect red blood cells = 10 cells / high power microscopic field (HP), and glomerular hematuria was confirmed; (2) The systolic blood pressure and / or diastolic blood pressure measured at different time points were higher than the 95th percentile of blood pressure in children and adolescents of the same sex, age and height, except for glucocorticoids; (3) Abnormal renal function was excluded due to insufficient blood volume; (4) Persistent hypocomplementaemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HLA allele (HLA-DQ/DR, HLA-A/B/C) frequency of childhood steroid dependent recurrent Idiopathic nephrotic syndrome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Association of HLA-DQ / DR alleles with relapse frequency, infection frequency and sustained remission time in patients with childhood SDNS / FRNS patients; | — |
Countries
China
Contacts
Public ContactHan Chan
National Clinical Medical Center for Children's Health and Diseases, Department of Nephrology, Children's Hospital Affiliated to Chongqing Medical University
Outcome results
None listed