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Ascorbic acid (vitamin C tablets) enhances the efficacy of targeted drugs in advanced renal cell carcinoma: a multicenter randomized controlled trial

Ascorbic acid (vitamin C tablets) enhances the efficacy of targeted drugs in advanced renal cell carcinoma: a multicenter randomized controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000034678
Enrollment
Unknown
Registered
2020-07-14
Start date
2020-07-01
Completion date
Unknown
Last updated
2020-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal cell carcinoma

Interventions

experimental group: Vitamin C tablets

Sponsors

Affiliated Hospital of Qingdao University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) over 18 years of age. 2) No restriction on gender. 3) patients with locally advanced renal cell carcinoma (loss of radical surgery), clear pathological diagnosis of puncture biopsy and targeted drug therapy (TKI inhibitor) were considered in clinical stage. 4) patients with metastatic renal cell carcinoma, who were pathologically diagnosed by primary resection or puncture biopsy, and planned to be treated with targeted drug therapy (TKI inhibitor). 5) the patient voluntarily participates and signs the informed consent form. 6) it is easy to understand and judge the requirements of clinical research.

Exclusion criteria

Exclusion criteria: 1) patients who have previously used targeted drugs or immunotherapy. 2) patients with hepatic and renal insufficiency who are not suitable for targeted drug therapy. 3) patients who can not be followed up in our hospital for a long time. 4) patients with severe internal environment disorder (such as acid-base balance disorder or electrolyte disorder). 5) according to the judgment of the researchers, there are other patients who are not suitable for clinical research.

Design outcomes

Primary

MeasureTime frame
Disease progression-free survival ;

Secondary

MeasureTime frame
Tumor specific survival time;Overall survival time;Objective remission rate;Duration of remission;

Countries

China

Contacts

Public ContactNiu Haitao

Affiliated Hospital of Qingdao University

niuht0532@126.com+86 18661804565

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026