Depressive disorder
Conditions
Interventions
A:OFC-tDCS 2mA 1time/day
B:OFC-tDCS 2mA 1time/day
C:dlPFC-tDCS 2mA 1time/day
D:dlPFC-tDCS 2mA 1time/day
E:OFC-Pseudo-stimulus 1time/day
F:dlPFC-Pseudo-stimulus 1time/day
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
14 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with depressive disorder diagnosed by dsm-5 (including unipolar depression and bipolar depression); 2. Patients aged from 14 to 65 years old; 3. Sex and nationality are not limited; 4. Patients with Hamilton depression score HAMD >= 8 and the first item >= 2; 5. For the patients who did not receive treatment related to depression other than drugs within two weeks of the inclusion time, the drugs and their doses remained unchanged during the treatment; 6. The objects whose educational level requires primary school or above; 7. Be able to accept the objects of numbness, slight tingling and other discomfort during the treatment process; 8. Adult patients should sign informed consent form (adult version), and minor patients should sign informed consent form (minor version) with their parents at the same time.
Exclusion criteria
Exclusion criteria: 1. Subjects with high suicide risk; 2. Pregnant women; 3. Patients with clinically diagnosed neurological disorders such as epilepsy, stroke, Alzheimer's disease, Parkinson's disease, etc.; 4. Patients with head trauma or skin diseases; 5. Patients with any implants or implantable devices interacting with tDCS current in the head; 6. Patients who had changed antidepressant drugs in the first two weeks; 7. Patients who have received any neuromodulation therapy in the past three months (e.g. (m) ect, (R) TMS, TES); 8. Patients with psychotic disorder, obsessive-compulsive disorder, phobia, panic disorder or stress-related disorder; 9. Patients with any type of substance abuse, such as alcohol and drugs, were included.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Positive and Negative Syndrome Scale;Pittsburgh Sleep Quality Index;cognitive ability;Daily activity and sleep;Electroencephalogram data; | — |
Primary
| Measure | Time frame |
|---|---|
| HAMD-17reduction rate; | — |
Countries
China
Contacts
Public ContactWu Hong
Shanghai Mental Health Center
Outcome results
None listed