Dexmedetomidine pre-administration plus 4 degrees C propofol attenuates propofol injection pain: a double-blind, randomized, placebo-controlled trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000034663

Enrollment

Unknown

Registered

2020-07-13

Start date

2020-07-01

Completion date

Unknown

Last updated

2020-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

propofol injection pain

Interventions

combination group:Dexmedetomidine 0.5ug/kg+4 degrees C propofol

Lidocaine group :Intravenous lidocaine 40mg

control group : saline injection

Eligibility

Sex/Gender

All

Age

18 Years to 54 Years

Inclusion criteria

Inclusion criteria: (1) The patient volunteered to participate in the study and signed the informed consent. (2) Over 18 years old. (3) Preoperative sedative drugs were not taken.

Exclusion criteria

Exclusion criteria: (1) Propofol/dex allergy; (2) Cardiovascular and cerebrovascular diseases/neurological diseases or psychiatric disorders.

Design outcomes

Primary

Measure	Time frame
heart rate;Mean Artery Pressure;pain assessment (VCS);pain assessment (NRS);surgical pleth index;	—

Countries

China

Contacts

Public ContactLiu Lihua

Affiliated Stomatological Hospital of Sun Yat-Sen University

308530673@qq.com+86 13112246868

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026