Chronic rhinosinusitis
Conditions
Interventions
Traditional treatment group:After oral administration of glucocorticoid for 2 weeks (prednisolone 0.5mg/kg gradually reduced after one week) + nasal spray budesonide nasal spray for 12 weeks (64ug 1 s
Sequential treatment group:Oral glucocorticoid 2 weeks after operation (prednisolone 0.5mg/kg gradually reduced after one week) + budesonide suspension drip nose for 4 weeks (0.5mg/each side, twice a
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with bilateral crswnp meeting the clinical diagnostic criteria for chronic rhinosinusitis; 2. Patients with jesrec score > 11, namely ECRs; 3. Patients with nasal polyps confirmed by pathology after operation; 4. Patients who can complete effective follow-up after operation; 5. Patients with informed consent.
Exclusion criteria
Exclusion criteria: 1. Non crswnp patients with fungal sinusitis, posterior nostril polyps, cysts, inverted papilloma, and parasite infection during or after operation; 2. Patients who received systemic glucocorticoids within 4 weeks before enrollment; 3. Patients allergic to macrolides; 4. Patients with mental system diseases, liver and kidney dysfunction, malignant tumor and cardiovascular disease; 5. Patients with contraindications to glucocorticoids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score;SNOT-22 scale;Lund-Kennedy score;Lund-Kennedy score;Morning serum cortisol;Percentage and absolute value of peripheral blood eosinophils; | — |
Countries
China
Contacts
Public ContactZhimin Xing
Peking University People's Hospital
Outcome results
None listed