Effect of Butorphanol on the half effective concentration of respiratory depression induced by target controlled infusion of propofol

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000034645

Enrollment

Unknown

Registered

2020-07-12

Start date

2020-07-13

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory depression

Interventions

Group 2:No Butorphanol

Group 1:give Butorphanol

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective general anesthesia; 2. aged 18-65 years old; 3. ASA I - class II; 4. BMI18-25 kg/m2; 5. No abnormality in liver and kidney function; 6. Preoperative airway assessment was normal (mallampatii-ii level, mouth opening degree > 3cm, chin distance > 6cm, head and neck mobility normal, no cervical spondylosis and sleep apnea syndrome).

Exclusion criteria

Exclusion criteria: A history of heavy smoking and alcohol abuse prior to surgery; A history of general anesthesia within 3 months before surgery; Use sedative and analgesic drugs before operation; Preoperative systolic blood pressure >=160mmHg, diastolic blood pressure >=110mmHg, heart rate >=110BPM;A history of serious substance abuse; Allergic to experimental drugs.

Design outcomes

Primary

Measure	Time frame
SpO2;Apnea time;Breathing rate;	—

Secondary

Measure	Time frame
BIS;Blood pressure;Heart rate;	—

Countries

China

Contacts

Public ContactFangJun Wang

Affiliated Hospital of North Sichuan Medical College

wfjlxy006@126.com+86 13458253172

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026