Cardiovascular diseases
Conditions
Interventions
PCSK9 intervention of drug conservative treatment group:Inject PCSK9 inhibitor
no PCSK9 intervention of drug conservative treatment group:no
Reperfusion PCSK9 intervention group:Inject PCSK9 inhibitor
Sponsors
Tianjin Union Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: The patients aged 18-80 years old, male or female, and confirmed by clinical symptoms, electrocardiogram and myocardial enzymes. The diagnostic criteria were as follows: guidelines for diagnosis and treatment of acute ST segment elevation myocardial infarction issued by Chinese Medical Association in 2017 and non ST segment elevation acute coronary syndrome in 2016.
Exclusion criteria
Exclusion criteria: Cardiogenic shock; after a long period of cardiopulmonary resuscitation; gastrointestinal bleeding; platelet count 2 times the upper limit of normal value; severe renal insufficiency (glomerular filtration rate estimated by Cockcroft Gault formula < 30ml · min-1 · 1.73m-2); end-stage tumor, septic shock, and foot-and-mouth disease, Hematological diseases, refractory hypertension, acute stroke, diabetic ketosis or hypertonic coma, pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma PCSK9;Coagulation factor VIII activity;CD63;Low density lipoprotein receptor associated protein 1 (LRP1); | — |
Countries
China
Contacts
Public ContactMingying Cao
Tianjin Union Medical Center
Outcome results
None listed