septic shock
Conditions
Interventions
experimental group:Intravenous injection of Nicorandil
control group:Intravenous injection of 0.9%NS
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients admitted to the ICU of our hospital were diagnosed as early septic shock (= 65 mmHg, and serum lactic acid level > 2 mmol/L despite adequate fluid resuscitation. 2. Patients and their families were informed and consented to the study.
Exclusion criteria
Exclusion criteria: 1. The patient had renal insufficiency before ICU treatment. 2. Patients were treated with RRT before ICU admission. 3. Treatment interruption or discharge or death within 7 days after admission to ICU; 4. Chronic renal insufficiency (diabetes mellitus, immunity) caused by other diseases and patients after kidney transplantation; 5. Pregnant women, lactating women, patients with malignant tumor and patients treated with immunosuppressive agents within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NGAL; | — |
Secondary
| Measure | Time frame |
|---|---|
| renal function (serum creatinine, blood urea nitrogen, Cystatin C);Infection degree;severity of disease;RRT use rate in 7 days of treatment;Average ICU treatment time;28-day mortality; | — |
Countries
China
Contacts
Public ContactWenjing Zhao
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed