Painless colonoscopy
Conditions
Interventions
Group A:Low dose (0.1mg/kg) rumazolam toluene sulfonate
Group B:Medium dose (0.12mg/kg) rumazolam toluene sulfonate
Group C:High dose (0.14mg/kg) Rumazolam toluene sulfonate
Sponsors
The First People's Hospital of Shuangliu District, Chengdu
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) A person older than 60 years of age who plans to undergo diagnostic or therapeutic colonoscopy (treatment procedures may include hemostasis, resection, ablation, decompression, removal of foreign bodies, etc.); (2) the American society of anesthesiologists (ASA) classification: ? ~ level III; (3) BMI <= 40kg /m2; (4) Sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Known allergy to benzodiazepines, flumazine, opioids, and naloxone; (2) long-term use of benzodiazepines and opioids; (3) opioids and alcohol abuse; (4) Previous history of neuropsychiatric illness; (5) received any study drug within 30 days prior to screening or less than 7 half-lives (whichever is older) or was likely to receive any related drug during study follow-up; (6) severe heart, lung, liver, and renal dysfunction (MET 2, basic SpO2 < 92%, abnormal biochemical indicators of liver and kidney function); (7) Audio-visual and communication barriers exist.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective sedation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| onset time;awakening time;HR;MAP;SpO2;Time out of the operating room;MMSE score before and after examination; | — |
Countries
China
Contacts
Public ContactSun Ting-ting
The First People's Hospital of Shuangliu District, Chengdu
Outcome results
None listed