Major depressive disorder
Conditions
Interventions
experimental group:theta tACS
control group:sham tACS
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: a. Aged 18-65 years; b. Major depressive disorder diagnosed by DSM-IV; c. Hamilton depression rating scale (HAMD-24) scores > 8; d. At least 2 weeks stable antidepressants treatment before enrollment.
Exclusion criteria
Exclusion criteria: a. Another mental disorder meets the DSM-IV criteria (except for major depressive disorder); b. Current of suicidal ideation or suicide attempts; c. Current or history of substance use disorder diagnosed by DSM-IV (except for nicotine dependence); d. Unstable physical diseases; e. History of epilepsy; f. Pregnant or lactating; g. History of electroconvulsive therapy, TMS, tDCS; h. History of a cochlear implant, cardiac pacemaker, and any brain devices or/and implants; i. Hyperalgesia, skin damage or inflammation in the stimulated area.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The MINI-International Neuropsychiatric Interview;Hamilton depression scale;Hamilton anxiety scale;Montgomery and Asberg depression rating scale;Young mania rating scale;The insomnia severity index;Pittsburgh sleep quality index;Montreal cognitive assessment;Electroencephalogram;Polysomnography;Functional magnetic resonance imaging;CANTAB Connect Research;Serum brain derived neurotrophic factor; | — |
Countries
China
Contacts
Public ContactJiahui Deng
Peking University Sixth Hospital
Outcome results
None listed