subjective cognitive decline
Conditions
Interventions
real rTMS-DLPFC:rTMS
sham rTMS-DLPFC:sham rTMS
real rTMS-precuneus:rTMS
sham rTMS-precuneus:rTMS
Sponsors
Affiliated Brain Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Self-reported persistent memory decline, which was confirmed by an informant; 2. Performance within the normal range on MMSE and MoCA (adjusted for age and education); 3. Clinical Dementia Rating (CDR) = 0; 4. Subjects aged between 50 and 80 years old; 5. Onset is less than 5 years; 6. Subjective Cognitive Decline Questionnaire (SCD-Q) score > 5.
Exclusion criteria
Exclusion criteria: 1. A past history of stroke (modified Hachinski Ischemic Scale Score of > 4), alcoholism, head injury, brain tumors, Parkinson's disease, epilepsy, encephalitis, major depression (excluded by HAMD), or other neurological or psychiatric illness (excluded by clinical assessment and case history); 2. Major medical illness (e.g., cancer, anemia, thyroid dysfunction, syphilis, or HIV); 3. Severe visual or hearing loss; 4. Unable to complete neuropsychological tests or with a contraindication for MRI, and 5. T2-weighted MRI showing major white matter (WM) changes, infarction, or other lesions (two experienced radiologists analyzed the scans).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognition socre;Network functional connectivity;SCD-Q; | — |
Countries
China
Contacts
Public ContactChen Jiu
Affiliated Brain Hospital of Nanjing Medical University
Outcome results
None listed