Effects of Betamethasone on Renal Dysfunction in Elderly Patients During Perioperative Period: a Multicenter, Prospective, Randomized, Controlled Clinical Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000034472

Enrollment

Unknown

Registered

2020-07-06

Start date

2020-07-06

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney injury

Interventions

Experimental group A:Betamethasone 8mg intravenous drip

Experimental group B:Betamethasone 16mg intravenous drip

Control group:Intravenous drip of equal amount of normal saline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged >= 65 years; 2. Elective abdominal surgery with general anesthesia; 3. ASA class in II ~ III; 4. Sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Liver or kidney function damage, hypertension, diabetes before surgery; 2. Preoperative history of use of nonsteroidal drugs and glucocorticoids; 3. Preoperative symptoms of infection; 4. Participated in other clinical trials.

Design outcomes

Primary

Measure	Time frame
Urinary NAG/Cr;Urinary Alb/Cr;	—

Secondary

Measure	Time frame
TNF-a;IL-6;Serum creatinine;Blood urea nitrogen;	—

Countries

China

Contacts

Public ContactXu Junmei

The Second Xiangya Hospital of Central South University

13975148864@139.com+86 13975148864

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026