Clinical research on innovative treatment of fungal keratitis: a randomized controlled trial.

Clinical research on innovative treatment of fungal keratitis

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000034467

Enrollment

Unknown

Registered

2020-07-05

Start date

2020-07-01

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fungal keratitis

Interventions

Conventional drug group:Conventional medication

Corneal collagen cross-linking group:Corneal collagen cross-linking

Continuous ocular lavage group:Continuous ocular lavage with antifungal

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Meet the following two conditions at the same time 1.Confocal microscopy shows clear mycelium structure or microscopy of corneal lesions or microbial culture results to confirm the diagnosis of fungi; 2. Corneal infection depth of invasion 3mm; 4. No corneal endothelial plaque; 5. Hypopyon depth < 1/4 anterior chamber.

Exclusion criteria

Exclusion criteria: Meet any of the following conditions 1.With endophthalmitis; 2.Those who can not cooperate with the inspection or cannot complete the follow-up. 3.Refuse to sign informed consent.

Design outcomes

Primary

Measure	Time frame
The best spectacle-corrected vision;Clinical healing time;Mycelium quantity and form in confocal microscope;Clinical recovery time;Corneal ulcer area;	—

Countries

China

Contacts

Public ContactLi Shaowei

Beijing Aier Intech Eye Hospital

lishaowei@csu.edu.cn18518483765

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026