NSCLC
Conditions
Interventions
Sponsors
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years old; 2. Patients with locally advanced or advanced (stage IIIB/stage IV) or relapsed non-squamous non-small cell lung cancer confirmed by histopathology; 3. The patient has not received systematic treatment for advanced or relapsed non-squamous non-small cell lung cancer; 4. Provide detectable specimens (tissue or pleural effusion or blood specimens) for genotype testing before entering the group. EGFR sensitive mutation test results are required to be positive (except for drug resistance mutation EGFR-T790M test results that are positive); 5. The subjects voluntarily joined the study, signed an informed consent form, had good compliance, and cooperated with follow-up.
Exclusion criteria
Exclusion criteria: 1. Histopathological type is small cell lung cancer or lung squamous cell carcinoma or mixed non-small cell lung cancer containing small cell lung cancer or lung squamous cell carcinoma; 2. Patients who have received any systemic anti-tumor treatment in the past; 3. Genetic testing results of patients with EGFR-T790M resistance mutation, ALK rearrangement or ROS1 fusion; 4. Patients who are receiving anti-tumor therapy from other systems; 5. Subjects with previous malignant tumors should be excluded unless complete remission is achieved at least 2 years before enrollment in the study and no other treatment is required during the study period; 6. People with multiple factors that affect oral medications (such as inability to swallow, post-gastrointestinal resection, chronic diarrhea, and intestinal obstruction, etc.); 7. Active lung disease (interstitial pneumonia, pneumonia, obstructive pulmonary disease, asthma) or active tuberculosis; 8. Have any uncontrollable clinical problems.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS;ORR;DCR; | — |
Countries
China
Contacts
Public ContactXingsheng Hu
National Cancer Center /Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed