Autism Spectrum Disorder
Conditions
Interventions
Traditional rTMS treatment group:Traditional rTMS treatment
Optimized rTMS treatment group:Optimized rTMS treatment
Optimized rTMS combined with oxytocin treatment group:Optimized rTMS combined with oxytocin treatment
Oxytocin alone treatment group:Oxytocin alone treatment
False stimulation + placebo treatment group:False stimulation + placebo treatment
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
10 Years to 15 Years
Inclusion criteria
Inclusion criteria: (1) Age 10-15 years; (2) Either male or female; (3) Conforms to the diagnosis of autism spectrum disorder in the Diagnostic and Statistical Manual of Mental Disorders-IV-Text RevisionDSM-5 and review by Autism Diagnostic Observation Schedule (ADOS)
Exclusion criteria
Exclusion criteria: (1) Suffer from serious physical diseases, such as congenital heart disease, thyroid disease, liver and kidney dysfunction, audio-visual impairment, etc.; (2) Accompanied by severe neurological diseases, with a clear family history or potential risks, such as brain trauma, encephalitis, epilepsy, high fever convulsions, birth injuries, abnormal EEG, etc.; (3) Suffer from definite or suspicious inherited diseases, such as trisomy 21 and fragile X syndrome; (4) In line with the diagnosis of other developmental diseases, such as simple mental retardation, simple language development disorder, selective silence, etc.; (5) Meet the diagnosis of other serious mental diseases, such as schizophrenia and bipolar disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Social Responsiveness Scale;Autism Behavior Checklist;Aberrant Behavior Checklist;Repetitive Behavior Scale-Revised;Child Behavior Checklist;Adaptive Behavior Assessment System - Second Edition;Ohio State University Autism Clinical Global Impression;Wechsler Intelligence Scale for Children Revised in China;Amplitude of Low Frequency Fluctuation;Functional Connectivity; | — |
Countries
China
Contacts
Public Contactwei chen
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed