?????
Conditions
Interventions
Experimental group:The treatment group was given rt-PA intravenous thrombolytic therapy (0.9 mg/kg, total amount <90 mg), and the brain CT was reviewed 24 hours later. Those without bleeding were give
Control group: The control group was given anti-platelet aggregation, lipid-lowering, stable plaque, blood circulation and other treatments.
Sponsors
Affiliated Hospital of North China University of Technology
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Onset time: from the last seemingly normal state to symptom discovery 4.5 hours; 2. When the patient wakes up or is found by the witness, there is neurological deficit; 3. NIHSS score >=4; 4. Patients with no or early changes < 1 / 3 distribution area of middle cerebral artery; 5. Patients with mismatched DWI / FLAIR images (DWI developed but flair did not develop); 6. Patients who meet all other indications of intravenous thrombolysis; 7. Patients with large vessel occlusion should be treated with endovascular therapy. The treatment principle should refer to the consensus of Chinese experts on endovascular treatment of acute ischemic stroke.
Exclusion criteria
Exclusion criteria: 1. Patients with severe diseases such as malignant hypertension, severe arrhythmia, acute myocardial infarction, etc; 2. Patients with acute infection, trauma, surgery, diabetic ketoacidosis and hypertonic coma recently; 3. Patients with severe primary diseases such as liver, kidney and hematopoietic system; 4. Patients with tumor and other organ failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurological deficit score (NIHSS);Modified Rankin Scale (mRS) score; | — |
Countries
China
Contacts
Public ContactChunyang Zhang
Affiliated Hospital of North China University of Technology
Outcome results
None listed