Liver Failure
Conditions
Interventions
experimental group:G-CSF+Conventional treatments
Sponsors
The Fifth Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-65 years; (2) Signed informed consent; (3) The diagnosis of HBV-ACLF was made with reference to Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL):an update and Update on Prevention, Diagnosis, and Treatment and of Chronic Hepatitis B:AASLD 2018 Hepatitis B Guidanceincluding a. basis of hepatitis B virus infection/hepatitis B/cirrhosis (positive the HBV surface antigen or serum HBVDNA for more than 6 months); b. Jaundice (serum bilirubin > 5mg/dL [>85umol/L]); c. coagulopathy (INR > 1.5 or prothrombin activity < 40%) without other causes; d. complicated within 4 weeks by ascites and/or encephalopathy; the severity of ACLF was assessed by the Model for End-Stage Liver Disease (MELD) (patients with MELD scores ranging 16-32 would be enrolled).
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating women; (2) Any detectable malignant tumor; (3) Bone marrow aplasia; (4) Concurrence of any other serious systemic diseases and psychiatric disorder (5) Recent or current participating in other clinical trial (6) Evidence of drug addiction during the last 1 year before enrollmen (7) Inability or unwillingness to sign the informed consent form or comply with the clinical trial requirements; (8) Any concurrent infection without effective anti-infection treatmen (10) Presentation of alcohol withdrawal symptom (11) Other virus co-infection; (12) Concurrence of cardiac,cerebral,or other system severe diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival rates; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactJinhua Hu
The Fifth Medical Center of Chinese PLA General Hospital
Outcome results
None listed