Repeated implantation failure in IVF
Conditions
Interventions
Experimental group:Intrauterine infusion of UCBMCs
Control group:No intrauterine infusion
Sponsors
The Affiliated Yantai Yuhangding Hospital of Qingdao University
Eligibility
Sex/Gender
Female
Age
25 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. After more than two times of high-quality embryo transfer or cumulative transfer of more than 4 embryos without clinical pregnancy, IVF-ET is proposed to be performed again; 2. The age is 25-40 years old; 3. The uterine morphology is basically normal, no abnormal echo in the uterine cavity, no ovarian cyst, and the basic endocrine is in the normal range; 4. Patients with high-quality frozen/thawed embryo transfer cycles 5. Patients willing to accept the treatment measures of this study (including the experimental group and the control group), signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with poor ovarian function reserve or PCOS; 2. Patients who had undergone unilateral oophorectomy previously; 3. Either of the couple has abnormal karyotype; 4. Positive serological screening of torch, hepatitis B, C, human immunodeficiency virus and syphilis; 5. Any patients that was inappropriate to be treated with this regimen.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Embryo implantation rate;Clinical pregnancy rate;Abortion rates; | — |
Secondary
| Measure | Time frame |
|---|---|
| Estrogen and progesterone levels on the day of embryo transfer;Endometrial thickness on the day of transplantation; | — |
Countries
China
Contacts
Public ContactHongchu Bao
The Affiliated Yantai Yuhangding Hospital of Qingdao University
Outcome results
None listed