STEMI
Conditions
Interventions
case series:Recombinant Human Prourokinase
Sponsors
Tianjin Chest Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years; 2. Patients confirmed ST-segment elevation myocardial infarction within 24 hours of onset; 3. Patients received thrombolytic therapy.
Exclusion criteria
Exclusion criteria: 1. Patients with recent (30 days) active bleeding (gastrointestinal ulcer, hemoptysis, hemorrhoids, hematochezia, etc.); 2. Surgery or biopsy within 3 months, cardiopulmonary resuscitation (extracorporeal heart compression, intracardiac injection, endotracheal intubation),vascular puncture of the compression site should not be performed and with history of trauma; 3. Unsatisfactory blood pressure control (blood pressure 180/110mmhg) or aortic dissecting aneurysm cannot be excluded; 4. Patients with history of hemorrhagic stroke and vascular embolism (including TIA); 5. Shock patients who do not respond to dilatation therapy or vasopressors; 6. Pregnant women, patients with bacterial endocarditis, patients with mitral valve disease and atrial fibrillation and high suspicion of thrombus in the left ventricle; 7. Patients with hemorrhagic disease or bleeding tendency, severe liver and kidney dysfunction, and progressive disease; 8. Diabetic patients with retinopathy; 9. Patients with consciousness disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of dissolved suppository;Whether the chest pain is relieved;The ST segment of electrocardiogram decreased by =50%;Target blood flow (TIMI) grade;Target blood flow (TIMI) grade;Clinical MACE Events (in-hospital); | — |
Countries
China
Contacts
Public ContactLi Chunjie, Fu Xianghua, Huo Yong
Tianjin Chest Hospital
Outcome results
None listed