Refractory depression and cardiac neurosis
Conditions
Interventions
intractable epilepsy and depression evaluated preoperatively with intracranial electrode implantation group verssus intractable epilepsy and cardiac neurosis who underwent preoperative assessment with
Sponsors
Xuanwu Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with intractable epilepsy and depression who underwent preoperative assessment with intracranial electrodes implantation 1. For patients who meet the diagnostic criteria of refractory epilepsy, intracranial electrodes were implanted for preoperative evaluation, and the implanted brain targets covered dorsolateral prefrontal lobe, lateral orbitofrontal gyrus, insular lobe or amygdala; 2. At the time of enrollment, it was confirmed by at least two attending physicians and above, which met the diagnostic criteria for major depressive disorder depressive episode in the diagnostic and Statistical Manual of mental disorders (DSM-V); 3. The total score of Hamilton Depression Rating scale-17 (HDRS-17) was more than or equal to 17 at the time of inclusion; 4. Aged 18-55 years old; 5. Right handed patients; 6. Patients who agree and sign informed consent. Inclusion criteria for patients with intractable epilepsy and cardiac dysfunction who underwent preoperative assessment with intracranial electrodes implantation 1. For patients who meet the diagnostic criteria of refractory epilepsy, intracranial electrodes were implanted for preoperative evaluation, and the implanted brain targets covered dorsolateral prefrontal lobe, lateral orbitofrontal gyrus, insular lobe or amygdala; 2. Clinical symptoms: palpitation, dyspnea, precordial pain, autonomic nerve dysfunction, etc. patients have strong subjective feelings, which affect the quality of life of patients; 3. Signs: lack of positive signs with important pathological significance (there may be slight increase of blood pressure, acceleration or deceleration of heart rate, etc.); 4. Auxiliary examination: lack of definite abnormal changes with important pathological significance (sinus tachycardia or bradycardia); 5. Aged 18-55 years old; 6. Right handed patients; 7. Patients who agree and sign informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with intractable epilepsy and depression evaluated preoperatively with intracranial electrode implantation: 1. Patients with other psychotic disorders such as bipolar disorder; 2. Patients with alcohol and psychotropic substances abuse / dependence; 3. Patients with high risk of serious impulsivity, suicidal tendency or self injury, with score of HDRS-17 item 3 (suicide) = 3; 4. Patients with severe or unstable organic diseases; 5. Patients with frequent seizures; 6. The researcher thinks that there is an inappropriate situation to participate in this study. Exclusion criteria for patients with intractable epilepsy and cardiac neurosis who underwent preoperative assessment with intracranial electrodes 1. Organic heart diseases such as coronary atherosclerotic heart disease, mitral valve prolapse syndrome, myocarditis, etc; 2. Patients with severe or unstable organic diseases; 3. Patients with frequent seizures; 4. The researcher thinks that there is not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mood state;Neuropsychological scale;Heart rate related indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| electroencephalogram;Magnetic resonance; | — |
Countries
China
Contacts
Public ContactWu Liyong
Xuanwu Hospital of Capital Medical University
Outcome results
None listed