Malignant bone tumor
Conditions
Interventions
Experimental group:Preoperative anticoagulation + postoperative routine anticoagulation
Control group:postoperative routine anticoagulation
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with malignant bone tumors that can undergo surgery; 2. Cpaprini>=2 points; 3. No venous thrombosis occurred before surgery; 4. Expected survival time >=3 months; 5. No blood system diseases; 6. The subjects voluntarily joined the study and signed an informed consent form with good compliance and cooperated with the follow-up.
Exclusion criteria
Exclusion criteria: 1. Have bleeding tendency or are receiving thrombolysis or anticoagulation treatment; 2. Patients with creatinine clearance < 30ml/min; 3. Obvious coughing blood in 2 months, or the daily hemoptysis up to amount of half a tea spoon (2.5ml) or more; 4. Significant bleeding symptoms or clear bleeding tendency within 3 months, such as gastrointestinal bleeding, hemorrhagic gastric ulcer, fecal occult blood at baseline and above; 5. Known hereditary or acquired bleeding and thrombotic tendency (such as hemophiliacs, coagulopathy, thrombocytopenia, hypersplenism, etc.); 6. Investigators judge other situations that may affect the progress of clinical research and the judgment of research results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative VTE; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative bleeding events; | — |
Countries
China
Contacts
Public ContactJianmin Li
Shandong University Qilu Hospital
Outcome results
None listed