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Clinical Study of Natural Killer Cell Infusion on the Immune Regulation and the Size of Viral Reservoir in HIV-1 Infected Patients

Clinical Study of Natural Killer Cell Infusion on the Immune Regulation and the Size of Viral Reservoir in HIV-1 Infected Patients

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000034309
Enrollment
Unknown
Registered
2020-07-01
Start date
2020-06-30
Completion date
Unknown
Last updated
2020-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

AIDS

Interventions

Experimental group:NK Cell Infusion

Sponsors

NHC Key Laboratory of AIDS Immunology (China Medical University), The First Affiliated Hospital of China Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-60 years; 2. HIV serum antibody was positive; 3. With ART more than 6 months and the viral load is lower than < 20 copies/ml; 4. No severe liver, heart and kidney dysfunction; 5. Fully understand the purpose, methods and possible side effects of the trial, and voluntarily participate and sign the informed consent form.

Exclusion criteria

Exclusion criteria: Subjects meeting any of the following criteria will not be included in this study. 1. Patients with severe opportunistic infection or tumor; 2. Patients with active hepatitis B, hepatitis C, syphilis, cytomegalovirus, EB virus or HSV-1 and HSV-2; 3. Suffering from more serious chronic diseases, metabolic diseases, neurological and mental diseases; 4. Patients with previous pancreatitis; 5. Suspected or confirmed history of alcoholism, smoking and drug abuse; 6. Patients participating in any other experimental drug study or received radiotherapy, chemotherapy and nuclear medicine examination in the past three months; 7. Intravenous injection is not acceptable; 8. Weak body, low compliance, or other conditions that failure to comply with the research requirements.

Design outcomes

Primary

MeasureTime frame
Vital Signs;CD4 T Cell Count;HIV Reservoir;NK cell number and function;Cytokines;Adverse reactions;

Secondary

MeasureTime frame
Routine Blood Test;Blood Biochemistry;Routine urine test;

Countries

China

Contacts

Public ContactHui Zhang

NHC Key Laboratory of AIDS Immunology (China Medical University), The First Affiliated Hospital of China Medical University

huizhang1218@163.com+86 13898181969

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026