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Effect of perioperative administration of ibuprofen on postoperative shivering: a randomized controlled trial.

Effect of perioperative administration of ibuprofen on postoperative shivering

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000034302
Enrollment
Unknown
Registered
2020-07-01
Start date
2020-09-01
Completion date
Unknown
Last updated
2020-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

shivering

Interventions

The placebo group:0.9% saline 250 ml was intravenously administered over 30 minutes
The ibuprofen group:Ibuprofen 10mg/kg (250ml) was intravenously administered over 30 minutes

Sponsors

Department of Anesthesiology, Obstetrics and Gynecology Hospital affiliated to Fudan University
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: (1) ASA < III; (2) Aged 20-60 years; (3) Indices of cardiac, liver, kidney, blood and other examinations are in the normal range; (4) According to GCP, all volunteers sign the informed consent.

Exclusion criteria

Exclusion criteria: (1) primary disease of important organs, such as cardiovascular and cerebrovascular diseases, hyperthyroidism, and neuromyopathy. (2) mentally or physically disabled; (3) severe obesity (BMI > 35 kg/m2); (4) a history of gastrointestinal ulcer or gastrointestinal bleeding; (5) allergy to aspirin or other non-steroidal anti-inflammatory drugs; (6) contraindications to neuraxial anaesthesia.

Design outcomes

Primary

MeasureTime frame
The incidence of severe early postoperative shivering;

Secondary

MeasureTime frame
The incidence of severe late postoperative shivering;Body temperature measured at forehead;Cochlear temperature;Body temperature measured at axilla;

Countries

China

Contacts

Public ContactShaoqiang Huang

Department of Anesthesiology, Obstetrics and Gynecology Hospital affiliated to Fudan University

timrobbins71@163.com+86 13918210787

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026