Hemorrhagic fever with renal syndrome, HFRS
Conditions
Interventions
Ribavirin treatment group:Ribavirin and conventional therapy
Conventional treatment group:Conventional treatment
Sponsors
Department of Infectious Diseases, The Second Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients within 6 days of onset and in the fever period (including fever, hypotension two-stage overlap, or fever, hypotension, oliguria three-stage overlap); 2. Patients aged 18 to 70 years; 3. Patients with HFRS case definition or serological confirmation; 4. Patients with Hgb >=100g/L and no history of ribavirin allergy; 5. Patients who agree to use ribavirin, collect specimens, report adverse events and follow up as required (28-30 days after discharge); 6. Objects without family planning within half a year; 7. Patients without history of chronic pancreatitis.
Exclusion criteria
Exclusion criteria: 1. Patients who have been sick for more than 7 days, have no fever at the time of admission, or have entered the stage of oliguria, transition and polyuria; 2. Patients with a history of allergy or other adverse reactions to ribavirin; 3. Patients with HGB 400u / L; 7. Patients with history of hemolytic anemia or T-Bil >3 ULN or i-bil >3 ULN.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum hantavirus load; | — |
Secondary
| Measure | Time frame |
|---|---|
| platelet count;Aspartate aminotransferase, AST;APTT;fibrinogen, Fib;creatinine, Cr;blood urea nitrogen, BUN;eGFR;IL-6;procalcitonin, PCT;urine volume;oliguria stage; | — |
Countries
China
Contacts
Public ContactLian Jianqi
The Second Affiliated Hospital of Air Force Medical University
Outcome results
None listed