postoperative neurocognitive disorders
Conditions
Interventions
PND group VS non-PND group:Nil
Sponsors
The Second Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing major lower limb fracture surgery with general anesthesia and/or regional block; 2. ASA grade I-III; 3. Aged 60-80 years; 4. Communication and communication are normal, with certain learning ability; 5. Patients who have signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe organ dysfunction; 2. Mental or neurological disorders such as schizophrenia, epilepsy, Parkinson's disease, or Alzheimer's disease; 3. Patients with recent brain injury, cerebral infarction, cerebral hemorrhage; 4. Patients with severe hearing, visual, or language disorders that cannot cooperate; 5. Patients with history of drug abuse or dependence; 6. Patients with history of alcoholism; 7. Patients with low literacy and simple Intelligence Scale (MMSE) < 23 points.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delirium scale score;Cognitive Scale score ("modified MMSE);soluble IL-6R;IL-6; | — |
Secondary
| Measure | Time frame |
|---|---|
| RASS score;VAS score;IL-1ß;IL-2;IL-4;IL-10;TNF-alpha; | — |
Countries
China
Contacts
Public ContactHu Jun
The Second Hospital of Anhui Medical University
Outcome results
None listed