Primary epithelial ovarian/fallopian tube carcinoma
Conditions
Interventions
Experimental group:Intraperitoneal perfusion chemotherapy was added during PDS
control group:Traditional therapy (PDS+ postoperative adjuvant chemotherapy)
Sponsors
Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years old; 2. Primary epithelial/fallopian tube carcinoma was pathologically confirmed and stage II~IV was estimated by preoperative imaging; 3. First-time patients who have not received treatment; 4.ECOG score 0-2; 5. The initial probe FOGOTTI score =4.0x10^9/L, hemoglobin >=80g/L, platelet >=80.0x10^9/L (after correction); Serum bilirubin <= ULN, ALT and AST <=ULN; Urea nitrogen (BUN) <=ULN, creatinine (Cr)<=ULN; 7. Obtain written informed consent.
Exclusion criteria
Exclusion criteria: 1. Have a history of other malignant tumor diseases (except thyroid cancer) or have received anti-tumor therapy (including chemotherapy, radiotherapy and surgery); 2. Severe uncontrolled internal and surgical disease or acute infection; 3. Female patients during pregnancy or lactation; 4. Gastrointestinal bleeding, perforation, intestinal obstruction or a history of related diseases; 5. Extensive adhesions in the pelvic cavity and abdomen; 6. Blood images and liver and kidney functions do not meet the requirements of chemotherapy; 7. Failure to complete all treatments and follow-up in our hospital.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| 5-year overall survival;2 years overall survival;There was no platinum interval between the two groups. (Platinum resistance/platinum sensitive recurrence);The incidence of grade 3-4 adverse reactions and quality of life were compared between the two groups.; | — |
Countries
China
Contacts
Public ContactFeng Weiwei
Department of Obstetrics and Gynecology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed