chronic kidney disease
Conditions
Interventions
experimental group:Oral supplement nephropathy dialytic total nutrient fluid and lifestyle guidance
control gorup:Lifestyle guidance
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Regular hemodialysis patient, Blood Purification Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. At least two of the following 3-9 items are met. If any of the other items are not met, they will not be included: 1. Patients with CKD who meet hemodialysis criteria between the ages of 18 ~ 75 years (including 18 and 75 years old) (the proportion of subjects of either sex is not less than 1/3); 2. Body mass index (BMI) = 5% within 3 months or >= 10% within 6 months; 4. Muscle mass reduction, >= 5% in 3 months or >= 10% in 6 months; 5. Serum albumin < 38g/L; 6. Serum prealbumin < 300mg/L; 7. Serum cholesterol level < 2.86mmol/L; 8. Protein intake of maintenance dialysis patients with no specific cause <0.8g/Kg/d for at least 2 months; 9. Unconscious low dietary energy intake <25Kcal/kg/d for at least 2 months; 10. Subjects should be willing to take appropriate contraceptive measures to avoid pregnancy between the study period and 1 month after the end of the study period; 11. The subjects understand and follow the study procedure, participate voluntarily, and sign the informed consent.
Exclusion criteria
Exclusion criteria: If any of the following is: 1. Participated in other clinical trials within 3 months before the trial; 2. Allergic constitution, such as allergic to drugs or food;Or those who are known to be allergic to the ingredients in ONS for this study; 3. Persons with severe heart and liver diseases or other acute digestive tract diseases or respiratory diseases, and persons with systemic diseases such as blood, endocrine, nervous and mental diseases; 4. Gastrointestinal and liver diseases that affect food absorption or metabolism (e.g., liver, kidney or gastrointestinal partial resection); 5. Acute diseases occurred during the pre-study screening stage or before the study medication; 6. Pregnant and lactating women; 7. Those who are unable to use effective contraception or who have had family planning for six months; 8. Taking other ONS preparations during the study; 9. Any subjects who, in the investigator's judgment, have reduced likelihood of inclusion (e.g. weak body, etc.), have a tendency to disobey during the study period, or have other lesions that complicate inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body composition measurement;serum albumin;anthropometric measuring;Grip strength; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life survey; | — |
Countries
China
Contacts
Public ContactYing Yao
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed