Depression
Conditions
Interventions
experimental group:Cognitive behavioral therapy and Antidepressants
Sponsors
Second People's Hospital of Guizhou Province
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Han nationality, aged 18-50 years, right-handed, junior high school or above; (2) Diagnosed as a "depressive episode" (diagnostic criteria: American diagnostic and statistical manual of mental disorders version 4 (dsm-iv)); (3) Hamilton depression scale (24 items) score >= 35; (4) The patients had not received antidepressant treatment, no history of electroconvulsive therapy and no history of transcranial magnetic stimulation therapy within 1 month before enrollment.
Exclusion criteria
Exclusion criteria: (1) Accompanied by other mental disorders, such as personality disorder, anxiety disorder, mental retardation, manic episode, schizophrenia, etc.; (2) Hamilton Anxiety Scale (HAMA) score 14; (3) Accompanied by brain organic diseases; (4) Depressive symptoms are caused by other organic diseases or drugs; (5) A family history of substance dependence or mental illness; (6) Women with contraindications in MRI scanning, pregnancy, lactation and pregnancy preparation; (7) Complicated with severe physical diseases. Note: according to the Columbia Classification Algorithm for Suicide Assessment (c-casa), Suicide attempt in this study is defined as: "a person who has the intention to end his/her life, has taken self-harming behavior but has not succeeded, has clear evidence of Suicide attempt or can be inferred from his/her behavior and circumstances". Termination criteria: (1) Diagnostic modification occurs; (2) Unable to complete homework or absent from CBT for more than 3 weeks; (3) Subjects are required to withdraw from this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional magnetic resonance;Hamilton Depression Scale; | — |
Countries
China
Contacts
Public ContactYanping Shu
The Second People's Hospital of Guizhou Province
Outcome results
None listed