Cervical intraepithelial neoplasia and invasive cancer
Conditions
Interventions
techonology 
based 
on 
deep 
learning
liquid-based 
cytology
Cobas 
Gold Standard:A standard colposcopy with directed four-quadrant biopsy at the squamo-columnar junction and endocervical curettage
test
Index test:Artificial 
intelligence 
cytology 
Sponsors
National Center for Chronic and Non-Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention.
Eligibility
Sex/Gender
Female
Age
25 Years to 64 Years
Inclusion criteria
Inclusion criteria: (1) Women aged 20-64 years; (2) Having intact cervis and no history of CIN; (3) Having self-reported genital symptoms in cervix, or suspected cervical invasive cancer in pelvic examination, including unexplained lower genital tract bleeding or contact bleeding, visible cervix ucler, tumor or neoplasm, or suspicious cancer; (4) Had any abnormality in previous screen, including abnormality in cytology, visual inspection with acetic acid or Lugols Iodine, or HPV positivity at least two months ago; (5) Receive colposcopy-directed biopsy for final diagnosis.
Exclusion criteria
Exclusion criteria: (1) women who were pregnant or in suckling period; (2) women who ever had history of cervical cancer or precancerous lesions; (3) women wo had mental diseases or cognitive disorder, or other health conditions that not enable to the participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;specificity;accuracy;positive predictive value;negative predictive value; | — |
Secondary
| Measure | Time frame |
|---|---|
| positive likelihood ratio;negative likelihood ratio;odds ratio; | — |
Countries
China
Contacts
Public ContactLinhong Wang
National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention
Outcome results
None listed