Cholelithiasis
Conditions
Interventions
Deep neuromuscular blockade group:Deep neuromuscular blockade
Moderate neuromuscular blockade group:Moderate neuromuscular blockade
Sponsors
The Second Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Laparoscopic cholecystectomy combined with choledocholithotomy under general anesthesia in the Second Affiliated Hospital of Nanchang University; 2. ASA I-III patients; 3. Patients aged 45-65 years old with body mass index of 18-30kg / m2; 4. Patients who are ethical, volunteer and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with current ophthalmic diseases (glaucoma, diabetic retinopathy, cataract, orbital tumor, optic nerve, diseases affecting the diameter of optic nerve sheath and retinal detachment); 2. Patients who have received ophthalmic operation; 3. Patients with preoperative intracranial hypertension, craniocerebral surgery and disease history; 4. Patients who have been allergic to anesthetics, muscle relaxants, family history of malignant hyperthermia and neuromuscular history; 5. Patients with primary hepatolithiasis and hepatobiliary system tumor, and acute obstructive suppurative cholangitis and pancreatitis; 6. Patients with serious heart and lung diseases, liver and kidney dysfunction and mental diseases, language communication disorders and refusing to participate in the experiment; 7. Patients with serious complications during operation (bleeding volume greater than 1000ml, severe anaphylactic shock, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optic nerve sheath diameter; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral oxygen saturation;Arterial carbon dioxide partial pressure;Central venous pressure;Tofr0.9 time; | — |
Countries
China
Contacts
Public ContactZhou Zhidong
The Second Affiliated Hospital of Nanchang University
Outcome results
None listed