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Efficacy and safety of endoscopic mucosal resection in the treatment of gastroesophageal reflux disease with hiatal hernia

Clinical study on minimally invasive endoscopic treatment of gastroesophageal reflux disease and hiatal hernia

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000034032
Enrollment
Unknown
Registered
2020-06-21
Start date
2020-06-18
Completion date
Unknown
Last updated
2020-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal reflux disease with hiatal hernia

Interventions

single arm:Hiatal Hernia-Endoscopic Submucosal Dissection,HH-ESD

Sponsors

Affiliated Hospital of Inner Mongolia Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. The gastroenterologist determines the clinical diagnosis (with typical symptoms of heartburn and acid reflux) of patients aged 18-75 years; 2. The 24h esophageal pH monitoring was consistent with: Demeester score > 30.0; 3. After systemic medical treatment for more than 2 months, the remission of symptoms is not obvious or the symptoms are still repeated after remission; 4. GERD with hiatal hernia is larger than 3cm in diameter; 5. Sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients who have received surgical treatment such as gastric folding and whose normal anatomical structures have been destroyed; 2. Esophageal stricture, severe dysphagia and esophageal motility disorders; 3. Severe cardiac dysfunction and pulmonary disease; 4. The coagulation function is poor, can not tolerate the operation; 5. Pregnant and lactating women.

Design outcomes

Primary

MeasureTime frame
24h esophageal pH monitoring;endoscopy;Esophagodynamic examination;Esophageal imaging;

Countries

China

Contacts

Public ContactHu Haiqing

Affiliated Hospital of Inner Mongolia Medical University

2312685624@qq.com+86 13674817979

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026