ESBL-producing Enterobacteriaceae urinary tract infection
Conditions
Interventions
Latamoxef group:treated with latamoxef 1g every 8hours
Piperacillin /tazobactam group:treated with Piperacillin/tazobactam 4.5h every 8 hours
PK group:treated with latamoxef 1g every 9 hours with a first dose of 1g or 2g
Sponsors
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patient with a diagnosis or a suspected diagnosis of Enterobacteriaceae urinary tract infection, and suitable to be treated with latamoxef. 2. Patient with ESBL high risk factors, such as history of repeated use of antibiotics, indwelling catheters, urinary tract or biliary tract calculus, history of ESBL-producing bacteria infection, hospitalization, ICU stay, old age, diabetic, immunodeficiency, mechanical ventilation. 3. Treatment length of systemic gram-negative bacteria active antibiotics less than 24 hours prior 72 hours of treatment, unless treatment failure can be identified. 4. Patient attend this research voluntary and sign the informed consent form. 5. Aged more than 18 years. for patients attending PK group, additional inclusion criteria is needed: (1) patient with an endogenous creatinine clearance rate in the range of 60-120 mL/min (calculated by CG equation). (2) patient with a BMI in the range of 18.5-26 kg/m2. (3) suitable for continuously sampling.
Exclusion criteria
Exclusion criteria: 1. Patients with prostatitis or suspected prostatitis, 2. History of kidney transplant, 3. Injury history of urinary tract or pelvis in 3 months, 4. Pregnant, or lactation period, 5. Critic ill patient, such as sepsis or MODS, 6. Mixed infection patients who needs combined antibiotics, 7. End stage of any disease, 8. Allergy history of latamoxef or piperacillin, 9. Attend other trials in 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| efficacy;PK parameters; | — |
Countries
China
Contacts
Public ContactYu Yunsong
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
Outcome results
None listed