Epilepsy
Conditions
Interventions
experimental group:phase I: electrical stimulation of the subthalamic nucleus (3v)
phase II: electrical stimulation (0v)
control group:phase I: electrical stimulation (0v)
phase II: electrical stimulation of the subthalamic nucleus (3v)
Sponsors
Xuanwu Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-60 years; 2. diagnosed as refractory epilepsy (resistant to AED medication for at least 2 years); 3. epileptogenic zone located in the motor or supplementary motor area; 4. with difficuty in resection surgery or refusal of resection surgery; 5. agree to participate into this study and sign on the informed consent form; 6. comply with the protocol of this study and agree on the follow-up examination as requested.
Exclusion criteria
Exclusion criteria: 1. with brain tumors or degenerative disorders of CNS; 2. with psychiatric disorders, cannot cooperate in the related examinations; 3. with morphological lesions in the subthalamic nucleus; 4. severe cognitive dysfunction, IQ < 50; 5. genetic generalized epilepsy or special inherited epilepsy; 6. pregnant women or those with high risk of hemorrhage; 7. other severe diseases and disorders, those with severe liver or lung dysfunction; 8. cannot undergo electrical stimulation due to objective causes; 9. abnormal results of laboratory examination in the screeing period, or those with significant clinical implications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| seizure frequency;seizure severity;quality of life; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive functions; | — |
Countries
China
Contacts
Public ContactTao Yu
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University
Outcome results
None listed