Glioblastoma
Conditions
Interventions
Surgical group:Maximum range of brain tumor resection +/ chemotherapy (temozolomide/bevacizumab)+/ radiotherapy + adjuvant therapy
Surgical only group:Maximum range of brain tumor resection +adjuvant therapy
Non-surgical group:Chemotherapy (temozolomide/bevacizumab)+/ radiotherapy + adjuvant therapy
Chemotherapy only group:Chemotherapy (temozolomide/bevacizumab)+ adjuvant therapy
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. The first postoperative pathological diagnosis was glioblastoma; 3. Brain MRI (plain scan + enhancement) should be reviewed every 3 months after discharge, or brain MRI should recur in time when symptoms, such as progressive headache, weakness or neurological symptoms, are present, so as to determine the time of recurrence; 4. Diagnosed as postoperative recurrence of glioblastoma after multidisciplinary consultation, or pathologically diagnosed as postoperative recurrence of glioblastoma after the second postoperative diagnosis; 5. Able to understand and willing to sign the informed consent; Ability and willingness to follow study and follow-up procedures.
Exclusion criteria
Exclusion criteria: 1. Patients with other malignant tumors; 2. The first operation was biopsy surgery; 3. The patient did not review MRI (plain scan + enhancement) within 24-72 hours after the first operation, so the degree of resection could not be accurately determined 4. The patient was unable to accurately determine the time of recurrence due to the lack of reexamination MRI data after the first operation; 5. The patient did not receive standard chemoradiotherapy after the first operation; 6. Severe uncontrolled infection or medical problems.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progressive epigenetic lifetime;overall survival;progression-free survival;quality of life;Brain MRI; | — |
Countries
China
Contacts
Public ContactZhiqiang Li
Zhongnan Hospital of Wuhan University,
Outcome results
None listed