refractory helicobacter pylori infection
Conditions
Interventions
experimental group:probiotics combined to Modified Dual Therapy
control group:Phased integrated therapy
Sponsors
People's Hospital of Shapingba district of Chongqing
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) from July 2020 to July 2022, patients aged 18-65 years old, male or female, will visit the outpatient and inpatient departments of the department of gastroenterology, chongqing shapingba district people's hospital; (2) meet the standard of refractory helicobacter pylori infection: the number of treatment failures of bismuth quadruplex therapy within 3 years with normal and full course of treatment (>=10 days) >=3 times; (3) chronic gastritis confirmed by gastroscopy, with or without healed gastric ulcer or duodenal bulbus ulcer;Rapid urease test (RUT) and 14c-urea breath test (14c-ubt) proved positive for HP infection; To be included, patients who meet each of the above criteria must sign an informed consent.
Exclusion criteria
Exclusion criteria: In the first four weeks of treatment, I have used PPI,H2 Receptor antagonists (H2RAs), antibiotics, traditional Chinese medicine containing antibacterial effects, bismuth, probiotics and other drugs.Pregnant or lactating women, patients with family planning during the study period;Alcohol abuse;At the same time take non - steroidal anti - inflammatory drugs, adrenocorticosteroids, anticoagulants;Allergic to the drugs used in this study;Severe concomitant diseases, such as heart disease, lung disease, liver disease, kidney disease, metabolic disease, mental disease, malignant tumor, etc. Previous gastric and esophageal surgery, or gastric mucosa with high-grade intraepithelial neoplasia;Difficulty in completing follow-up or the presence of other factors affecting compliance.The above standard accords with one item to want to exclude namely.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical efficacy of drugs; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse drug reaction;patient compliance;factors affecting the rate of therapeutic eradication; | — |
Countries
China
Contacts
Public ContactYang Fan
People's Hospital of Shapingba district of Chongqing
Outcome results
None listed