Migraine
Conditions
Interventions
Sponsors
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for MwoA 1. Diagnosed as migraine without aura according to the diagnostic criteria specified by the ICHD-III, IHS 2018 2. Male and female adults aged 18–65, right handed 3. Initial onset of migraines prior to the age of 50 years 4. Experience of acute migraine attacks at a frequency of 2 to 8, but less than 15 days of attacks per month during the previous 3 months and during baseline measurement 5. Experience of migraine attacks for at least 1 year 6. Provision of written, informed consent by the patients. Inclusion criteria for HC 1. Male and female adults aged 18–65with a normal physical examination and without any family history of sever diseases 2. No history of neurological diseases, and no major physical diseases and trauma history 3. Right handed, roughly matched with the sex, age and education of the MwoA participants selected 4. Without any contraindications for MRI scans, such as pacemakers, cardiac defibrillators, cochlear implants or claustrophobia
Exclusion criteria
Exclusion criteria: 1. Patients with headache caused by organic diseases; 2. Patients with nervous system disease, immune deficiency, hemorrhagic disease or allergy; 3. Patients who had used drugs to control migraine attack within 1 month before admission; 4. Patients with alcohol or other drug abuse; 5. Patients participating in other clinical trials at the same time; 6. Pregnant or lactating women, or patients who plan to be pregnant within 6 months; 7. Patients with any contraindications (such as pacemakers, aneurysm clips, artificial heart valves, ear implants or metal fragments, eyes, skin or body foreign matters) on MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the frequency of migraine attacks;Brain functional magnetic resonance data; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Visual analogue scale (VAS) for headache;acute medication intake;Migraine-specific quality-of-life questionnaire (MSQ);The self-rating anxiety scale [SAS];The self-rating depression scale[SDS];number of participants with adverse events (AEs) and serious adverse events (SAEs);number of migraine days; | — |
Countries
China
Contacts
Public ContactWang Jun
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Outcome results
None listed