Issues related to analgesia after abdominal surgery
Conditions
Interventions
experimental group:Nalbuphine 0.5mg/ml + sufentanil 0.5µg/ml + tropisetron 5mg
control group:Sufentanil 1µg/ml + tropisetron 5mg
Sponsors
Qingdao Municipal Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with abdominal surgery (single abdominal incision >= 5 cm); 2. ASA I~II level; 3. Aged 18-65 years, regardless of gender; 4. Body Mass Index (BMI): 29kg/m2 >= BMI >= 18.5kg/m2;
Exclusion criteria
Exclusion criteria: 1. Poor compliance and unable to cooperate with the operation; 2. Women who are pregnant or breastfeeding; 3. Acute heart failure; unstable angina; myocardial infarction within 6 months before screening; resting ECG heart rate = 160 mmHg or SBP = 1.5 * ULN, blood creatinine is greater than the upper limit of normal value; 6. Patients with severe respiratory tract lesions (obstructive sleep apnea syndrome, acute respiratory infections, acute onset of chronic obstructive pulmonary disease, uncontrolled asthma, etc.); 7. The electrolyte is not within the following normal range: Na+ (130150 mmol/L), K+ (3.55.5 mmol/L), Ca2+ (2.02.9mmol/L); 8. Abnormal blood coagulation function (PT or APTT exceeds 1.5 times the upper limit of normal value); 9. History of neurological diseases; history of chronic pain; drug addiction and alcoholism; long-term application of opioids; 10. People who are allergic to nalbuphine hydrochloride or its components, patients with a history of allergy to opioids;11. Patients with restricted gastric emptying and gastroparesis; 12. Patients with weakened intestinal peristalsis and intestinal obstruction; 13. Those who have participated in clinical trials of other drugs in the last 4 weeks; 14. With other circumstances, the investigator believes that it is not suitable for the selected patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain score (rest and activity) (each observation time); | — |
Secondary
| Measure | Time frame |
|---|---|
| Total number of PCA and effective number of PCA;Ramsay sedation score;Evaluation of patients' satisfaction with the analgesic effect after 48h;Incidence of adverse reactions such as respiratory depression, nausea and vomiting, drowsiness, and itchy skin;Postoperative catheter removal time, gastrointestinal function recovery time (exhaust time), time to start activity and length of hospitalization; | — |
Countries
China
Contacts
Public ContactMingshan Wang
Department of Anesthesiology, Qingdao Municipal Hospital
Outcome results
None listed