H.pylori
Conditions
Interventions
Dual therapy group:Esomeprazole 20 mg, and amoxicillin 750 mg
4 times a day (among them, 16 units use amoxicillin 1000mg, 3 times a day). The group receives the regime for 14 days.
Quadruple therapy group:Esomeprazole 20 mg, bismuth potassium citrate 220 mg, amoxicillin 1000 mg, and clarithromycin 500mg
twice a day.The group receives the regime for 14 days.
Sponsors
Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients, aged between 18-65 years; 2. Patients diagnosed as HP infection by C13 / C14 urea breath test or immunohistochemical staining of biopsy samples; 3. Patients with indications of HP eradication and no antagonistic factors; 4. Patients who have not received HP eradication treatment before; 5. Patients who did not take antibiotics, bismuth and antibacterial traditional Chinese medicine 4 weeks before the treatment, and those who did not take PPI, H2 receptor antagonists and other drugs that affect the activity of HP 2 weeks before the treatment; 6. Patients were informed and agreed to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Patients with severe heart, liver, lung and kidney dysfunction and low immunity; 2. Patients with penicillin or program related drug allergy contraindications; 3. Patients with mental illness and communication disorder; 4. Pregnant and lactating patients; 5. Patients with organic diseases such as gastrointestinal tumor and gastrointestinal hemorrhage; 6. Patients who are participating in other clinical trials; 7. The researchers think it is not suitable for the patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The eradication rate of Helicobacter pylori; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse events;patient adherence;Cost of drug; | — |
Countries
China
Contacts
Public ContactPeiyuan Li
Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of science and technology
Outcome results
None listed