Colorectal cancer
Conditions
Interventions
Probiotic group:Oral probiotics during neoadjuvant therapy
control group:placebo
Sponsors
Weihai Central Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with colorectal cancer diagnosed by endoscopy and pathology were evaluated by ultrasonography and MRI to meet the indications of neoadjuvant chemotherapy; 2. The patients who were first diagnosed had not received anti-tumor treatment before; 3. Patients who obtain the consent of patients or their guardians and sign the informed consent of the experiment.
Exclusion criteria
Exclusion criteria: 1. Patients with poor cardiopulmonary function and other diseases unable to tolerate chemotherapy; 2. Patients with long-term use of antibiotics or intestinal diseases leading to imbalance of intestinal flora; 3. Patients or their guardians do not agree with neoadjuvant chemotherapy or experiment before operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical stage of rectal cancer; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions;Immune Function; | — |
Countries
China
Contacts
Public ContactLong Li
Weihai Central Hospital
Outcome results
None listed