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Individualized treatment of advanced gastric cancer, ovarian cancer, breast cancer and bladder cancer based on malignant hydrothorax and ascites-derived MiniPDX and the exploration of its epigenetic mechanism

Individualized treatment of advanced gastric cancer, ovarian cancer, breast cancer and bladder cancer based on malignant hydrothorax and ascites-derived MiniPDX and the exploration of its epigenetic mechanism

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000033929
Enrollment
Unknown
Registered
2020-06-17
Start date
2020-07-01
Completion date
Unknown
Last updated
2020-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Advanced gastric cancer, ovarian cancer, breast cancer and bladder cancer

Interventions

case series:N/A

Sponsors

The First Affiliated Hospital, College of Medicine, Zhejiang University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients with advanced gastric cancer, ovarian cancer, breast cancer and bladder cancer confirmed by histopathology; 2. Patients who can collect malignant pleural and ascites samples and separate sufficient tumor cells; 3. CT / MRI can be used to evaluate the curative effect of patients with objective tumor focus meeting the criteria of RECIST 1.1; 4. Patients with KPS >= 60 and expected survival time >= 3 months; patients who can tolerate chemotherapy and targeted treatment according to comprehensive evaluation, and who need radiotherapy, should be after chemotherapy and targeted treatment to avoid affecting the effect of the former. 5. Patients who voluntarily participate and sign informed consent have good compliance and can actively treat and cooperate with follow-up.

Exclusion criteria

Exclusion criteria: 1. Patients with unplanned reoperation after operation; 2. Patients with other tumors or a second tumor were found during the treatment, which interfered with the study; 3. Blood biochemical examination indicates that the patient is not suitable to continue chemotherapy or the chemotherapy is delayed.

Design outcomes

Primary

MeasureTime frame
overall response rate;overall survival;progression-free survival;

Countries

China

Contacts

Public ContactJiang Qi

The First Affiliated Hospital, College of Medicine, Zhejiang University

598822981@qq.com+86 13777840699

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026