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Effect of prebiotics on intestinal flora and its mechanism: a randomized controlled trial.

Effect of prebiotics on intestinal flora and its mechanism

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000033913
Enrollment
Unknown
Registered
2020-06-16
Start date
2020-06-05
Completion date
Unknown
Last updated
2020-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Interventions

FOS group:FOS
GOS group:GOS
Inulin group:Inulin
XOS group:XOS
Lactulose group:Lactulose
Resistant dextrin group:Resistant dextrin
Stachyose group:Stachyose
Soybean oligosaccharides group:Soybean oligosaccharides

Sponsors

Jiangnan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Local healthy people aged 18-65 years can be both male and female. 2. BMI index is between 19-35 kg/m2 (inclusive).

Exclusion criteria

Exclusion criteria: 1. Patients with chronic / infectious / major diseases diagnosed by the hospital, or with respiratory and / or gastrointestinal diseases, as well as serious abnormalities in physical examination; 2. Any abnormal physical condition or medical condition affecting the gastrointestinal tract or the administration of experimental prebiotic products; 3. Patients who have undergone abdominal or intestinal surgery within one year. 4. Patients who use drugs related to digestive tract diseases within 2 weeks, such as antispasmodic drugs, cathartic drugs, antidiarrheal drugs and other drugs that affect intestinal peristalsis. 5. Patients who currently or recently (within 1 month) use microecological agents (probiotics / prebiotics / synbiotics), dietary supplements, Chinese herbal medicines, or take large doses of vitamins or minerals; 6. Those patients who currently or recently (1 month) or long-term use antibiotics; 7. Patients who have long-term consumption of yogurt, cheese, probiotic drinks, fermented products and other probiotic foods; 8. Lactose intolerant patients; 9. Those who have significant changes in their eating habits in the near future (within one month), such as starting to eat a diet rich in fiber, etc.; 10. Women who are pregnant, breast-feeding or wish to be pregnant; 11. Subjects with convulsion symptoms or mental history; 12. Subjects of other clinical studies at present or in the near future (within one mo nth).

Design outcomes

Primary

MeasureTime frame
Composition and abundance of intestinal microflora in feces;Fecal Mategenome;

Secondary

MeasureTime frame
Fecal short-chain fatty acids;Absolute quantitative of fecal flora;

Countries

China

Contacts

Public ContactQiao Qixiao

School of Food Science and Technology, Jiangnan University

zhaiqixiao@jiangnan.edu.cn+86 15961760920

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026