The Effects of Duloxetine on Pain and Emotional Function Following Total Knee Arthroplasty in Patients with Depression Symptoms: a Randomized Controlled Trial.

The Effects of Duloxetine on Pain and Emotional Function Following Total Knee Arthroplasty in Patients With Depression Symptoms: a Randomized Controlled Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000033903

Enrollment

Unknown

Registered

2020-06-16

Start date

2020-06-15

Completion date

Unknown

Last updated

2021-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty

Interventions

Duloxetine group:Duloxetine 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery).

Placebo group:Placebo 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery).

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Patients to be treated with total knee arthroplasty; 2. Patients aged 18-85 years; 3. Patients with preoperative depression symptoms (17-items Hamilton Depression Scale score more than 8); 4. Patients who sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with duloxetine allergy; 2. Patients who exposured to SNRIs or selective serotonin reuptake inhibitors or tricyclic antidepressant or monoamine oxidase inhibitor within 6 months prior to the surgery; 3. Patients with high preoperative inflammatory factor (CRP > 20mg / L); 4. Patients with abnormal platelet function or coagulation function before operation; 5. Patients with abnormal liver and kidney function. 6. ASA status IV

Design outcomes

Primary

Measure	Time frame
VAS pain score;Postoperative morphine consumption;Hamilton Depression Scale;SF-12;	—

Secondary

Measure	Time frame
Range of motion;knee society score;Womac score;complication;	—

Countries

China

Contacts

Public ContactZongke Zhou

West China Hospital of Sichuan University

zhouzongke@scu.edu.cn+86 18980601028

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026