Colorectal cancer
Conditions
Interventions
Experimental group:Clostridium butyricum
Sponsors
Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed as colorectal adenocarcinoma by preoperative fiberoptic colonoscopy and pathological examination; 2. Radical surgery for laparoscopic/open colon cancer/rectal cancer; 3. Aged 18 to 80 years old; 4. The laboratory test results before entering the group meet the following surgical conditions: neutrophil (ANC) >= 1.5x10^9/L, platelet (PLT) >=100x10^9/L, total bilirubin (TBI) <=1.5 ULN (2mg/dl), alanine aminotransferase (ALT), aspartate aminotransferase (AST) <=2 ULN; coagulation parameters are in the normal range; 5. The patient has no psychological, family, social, or geographic restrictive factors that affect protocol compliance and follow-up time; 6. Patient signs informed consent.
Exclusion criteria
Exclusion criteria: 1. Other types of colorectal cancer (adenosquamous carcinoma, squamous cell carcinoma, neuroendocrine tumors, clear cell carcinoma, spindle cell carcinoma, undifferentiated carcinoma) 2. Those who have recently taken similar micro-ecological preparations; 3. Those with acute or chronic infections or infections before surgery; 4. Those who cannot take probiotics on time according to the research plan; 5. Radical surgery was not performed for various reasons during the operation; 6. Acute abdomen: intestinal obstruction, intestinal crush, peritonitis, etc.; 7. Merging other parts to transfer; 8. There are serious heart, lung, liver, and kidney diseases, and the operation cannot be tolerated; 9. Liver disease active period or abnormal liver function, ALT, AST, TBIL are more than 2 ULN; 10. Renal impairment, Cr >=2 ULN or BUN >=2 ULN; 11. Subjects whose blood leukocytes are below the lower limit of normal, or platelets are below the lower limit of normal, or have other blood system diseases; 12. Those with mental illness or intellectual disability who cannot describe their feelings correctly; 13. Severe coagulation mechanism disorder, bleeding tendency; 14. There are serious uncontrolled medical diseases, recent history of myocardial infarction (within 3 months); acute infection; 15. After intervention treatment, uncontrolled severe hypertension and severe diabetes patients; 16. Those who are allergic to test drugs; 17. Have a history of alcohol, drug or drug abuse; 18. Those who have participated in any drug trial within 3 months before being selected; 19. The investigator believes that other candidates are not suitable for this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First flatus time;Intestinal flora diversity; | — |
Secondary
| Measure | Time frame |
|---|---|
| T lymphocyte subsets;Serum inflammatory factor; | — |
Countries
China
Contacts
Public ContactYanlei Ma
Department of Colorectal Surgery, Fudan University Shanghai Cancer Center
Outcome results
None listed