Infertility
Conditions
Interventions
Repeated transplantation failure D3 control group (thaw on the day):Thaw D3 embryos on the day of transfer
Repeated transplantation failure D5 control group (thaw on the day):Thaw D5 embryos on the day of transfer
D3 experimental group of repeated transplant failure (thaw one day in advance):Thaw D3 embryos one day in advance
D5 experimental group of repeated transplant failure (thaw one day in advance):Thaw D5 embryos one day in advance
Routine D3 control group (thawed on the day):Thaw D3 embryos on the day of transfer
Routine D5 control group (thawed on the day):Thaw D5 embryos on the day of transfer
Routine experimental group (thaw one day in advance):Thaw D3 embryos one day in advance
Routine D5 experimental group (thaw one day in advance) :Thaw D5 embryos one day in advance
Sponsors
Department of Reproductive Medicine, Jinan Central Hospital Affiliated to Shandong University
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: Patients with repeated transplant failure: Inclusion criteria: (1) Aged <=35 years old; (2) Regular menstrual cycle; (3) Baseline follicle stimulating hormone (FSH) <12 IU/L; (4) Infertility, pure fallopian tube or/and male factor; (5) experienced two or more ET cycle failures; (6) At least 2 high-quality day 3 embryos or 1 high-quality day 5 blastocyst are used for ET. Routine patients: Inclusion criteria: (1) Aged <=35 years old; (2) Regular menstrual cycle; (3) Baseline follicle stimulating hormone (FSH) <12 IU/L; (4) Infertility, pure fallopian tube or/and male factor; (5) Have not experienced two or more ET cycle failures; (6) At least 2 high-quality day 3 embryos or 1 high-quality day 5 blastocyst are used for ET.
Exclusion criteria
Exclusion criteria: Patients with repeated transplant failure: The exclusion criteria are as follows: (1) Abnormal uterus, such as adenomyosis, endometriosis, endometrial polyps or Asherman syndrome; (2) Abnormal ovaries, such as low ovarian response and polycystic ovary syndrome (PCOS); (3) The endometrial thickness of FET day is <7 mm. Routine patients: The exclusion criteria are as follows: (1) Abnormal uterus, such as adenomyosis, endometriosis, endometrial polyps or Asherman syndrome; (2) Abnormal ovaries, such as low ovarian response and polycystic ovary syndrome (PCOS); (3) The endometrial thickness of FET day is <7 mm.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical implantation rate;Clinical pregnancy rate;Positive rate of human chorionic gonadotropin (HCG); | — |
Countries
China
Contacts
Public ContactBin Wu
Ji'nan Central Hospital Affiliated to Shandong University
Outcome results
None listed