Polycystic Ovary Syndrome
Conditions
Interventions
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: For participants: 1. aged 20-35 years old; 2. diagnosis of PCOS according to the Rotterdam 2003 criteria (Rotterdam, 2004) which requires at least two of the following three criteria: (1) Rare ovulation and/or anovulation (less than eight menstrual cycles in one year or menstrual cycles longer than 35 days) (Azziz et al., 2004); (2) clinical and/or biochemical signs of hyper androgenism; (3) polycystic ovaries (each ovary presents 12 or more follicles measured 2-9 mm in diameter and/or ovarian volume >= 10 ml) and exclusion of other aetiologies of high androgens (e.g. Congenital adrenal hyperplasia, cushing's syndrome, androgen-secreting tumors, etc). For control group: 1. healthy women who underwent regular physical examination every year before participation; 2. aged 20-35 years old; 3. regular menstrual cycles (28-35 days).
Exclusion criteria
Exclusion criteria: Experimental group: 1. pregnant state; 2. bad habits(e.g. smoking, drinking alcohol, etc); 3. History of hormone drugs within at least previous three months, including ovulation-promoting drugs, oral contraceptives, oestrogenic, anti-androgenic drugs and other hormonal drugs. Control group: 1. clinical or biochemical signs of hyper androgenism; 2. pregnant state; 3. smoking or drinking; 4. bad habits(e.g. smoking, drinking alcohol, etc); 5. history of hormone medicine within at least previous three months the same as PCOS patients; 6. Vaginal or colorectal ultrasound suggested changes of polycystic ovaries.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Using high-throughput proteins chip technology (including 640 cytokines) to compare expression of proteins in mixed serum of parts of samples between IR and Non-IR group; | — |
Secondary
| Measure | Time frame |
|---|---|
| he clinical characteristics and laboratory indications between IR and Non-IR group; | — |
Countries
China
Contacts
Public ContactFang Wang
Lanzhou University Second Hospital
Outcome results
None listed