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Effect of Expression and Localization of Intestinal Aquaporin on Intestinal Mucosal Injury and Intestinal Bacterial Translocation in Patients with Acute Intestinal Perforation Accompanied by Sepsis

Effect of Expression and Localization of Intestinal Aquaporin on Intestinal Mucosal Injury and Intestinal Bacterial Translocation in Patients with Acute Intestinal Perforation Accompanied by Sepsis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000033859
Enrollment
Unknown
Registered
2020-06-14
Start date
2020-06-13
Completion date
Unknown
Last updated
2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Intestinal Perforation

Interventions

acute appendicitis:nothing
chronic appendicitis:nothing

Sponsors

Shaoxing People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed as acute and chronic appendicitis; 2. Patients who are operated under general anesthesia; 3. Patients aged 18-80 years; BMI 18-25.

Exclusion criteria

Exclusion criteria: 1. Diabetic patients; 2. Patients with chronic inflammatory or infectious diseases (such as rheumatoid arthritis, lupus and enteritis); 3. Cancer patients; 4. Patients with blood diseases or serious liver and kidney diseases.

Design outcomes

Primary

MeasureTime frame
Determination of Escherichia coli DNA in blood;Plasma concentration of diamine oxidase;Plasma concentration of D- lactic acid;Morphological examination by HE staining;Aquaporins 1, 2, 3, 4, 7, 8, 10 positioning;expression of Aquaporins 1, 2, 3, 4, 7, 8, 10;—

Countries

China

Contacts

Public ContactLi Yuhong

Shaoxing People's Hospital

yuh_li@qq.com+86 13758147990

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026