Comparison of neostigmine vs. sugammadex for recovery of early postoperative muscle strength after neuromuscular block by means of ultrasonography in microlaryngeal surgery

Recovery of early postoperative muscle strength after deep neuromuscular block by means of ultrasonography with comparison of neostimine versus sugammadex as reversal drugs: a randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000033832

Enrollment

Unknown

Registered

2020-06-14

Start date

2020-07-01

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative residual neuromuscular blockade

Interventions

NEO:neostigmine

SUG:sugamadex

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-65 years old who will undergo microlaryngeal surgery under general anesthesia; 2. ASA status I–II.

Exclusion criteria

Exclusion criteria: 1. Severe kidney disease (glomerular filtration rate<50 ml/min); 2. Severe liver disease (Child-Pugh B or C); 3. Allergic to neostigmine or sugammadex; 4. Difficult airway; 5. Acute and chronic alcoholism; 6. Previous neurological diseases; 7. Diaphragmatic paralysis; 8. Pregnancy or nursing; 9. Arrhythmia.

Design outcomes

Primary

Measure	Time frame
thickness of geniohyoid muscle;maximum displacement of hyoid;	—

Secondary

Measure	Time frame
thickness fraction of diaphragm;thickness fraction of parasternal intercostal muscle;thickness of abdominal wall muscle;handgrip strength;dosage of anesthetics;	—

Countries

China

Contacts

Public ContactYing Xiao58 Second Zhongshan Road, Yuexiu District, Guangzhou, Guangdong, China

The First Affiliated Hospital of Sun Yat-Sen University

xying2603@163.com+86 13570521662

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 16, 2026