Stroke
Conditions
Interventions
Experimental group:Upper Limb-Hand Movement—Naming Task & regular training
control group:Language training & regular training
Health Participant Group (not randomization):without intervention
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria for stroke patients: 1. the patients with the first stroke (cerebral infarction and cerebral hemorrhage) with the course of 3 months to 2 years; 2. The patients with cerebral infarction meet the diagnostic criteria of 2014 Chinese guidelines for the diagnosis and treatment of acute ischemic stroke; 3. The patients with cerebral hemorrhage meet the diagnostic criteria of 2014 Chinese guidelines for the diagnosis and treatment of cerebral hemorrhage; 4. Patients with cerebral infarction or cerebral hemorrhage confirmed by CT or MRI; 5. Patients diagnosed as non fluent aphasia by Western Aphasia Battery (WAB); 6. Patients who have not received noninvasive brain stimulation evaluation and / or treatment before participating in the trial; 7. Patients whose mother tongue is Chinese, 18 years old = age = 85 years old (subject to the day of signing the informed consent), regardless of gender; 8. The vital signs of the patients were stable with few or no serious complications; 9. Patients with right handedness; 10. Brunnstrom grade: upper limb III, hand III; evaluation of free hand muscle strength: upper limb muscle strength above 2 +; 11. Modified Rankin Scale (MRS) score: 1-4; 12. NIHSS score: 1-20; 13. Patients who signed the informed consent and were able to complete the trial according to the protocol. Inclusion criteria for healthy adults: 1. The age of the control group matched that of the experimental group; 2. Right handed objects; 3. Subjects with normal cognition and intelligence, no special symptoms and signs, no previous special diseases, no brain tumors or other brain diseases, no mental history, no epilepsy history; 4. Subjects without any abnormal laboratory and imaging examination results; 5. The subjects who sign the informed consent and can complete the test according to the scheme.
Exclusion criteria
Exclusion criteria: Exclusion criteria for stroke patients: 1. The condition worsens and new cerebral infarction or cerebral hemorrhage appears; 2. Before the onset of the disease, there was speech disorder or the onset of the disease combined with serious dysarthria; serious speech, attention, hearing, vision, intelligence, spirit or cognitive disorders (MMSE < 25 points) 3. Severe spasm or pain; 4. Patients who have serious organ failure such as heart, lung, liver and kidney; uncontrolled hypertension, arrhythmia, serious coronary heart disease, diabetes mellitus with poor control; patients with other nervous system diseases such as Alzheimer's disease and Parkinson's syndrome; 5. Patients with previous cognitive impairment, attention deficit, neuropsychiatric history, drug abuse and alcoholism; 6. Patients who can't cooperate with functional assessment and have poor compliance; 7. Patients who recently participated in other clinical trials. Exclusion criteria for healthy adults: 1. Objects with (potential) mental problems (simple mental assessment <=25 points); 2. Participants in other clinical trials during pregnancy and the same period; 3. Subjects who can not complete the study completely and have poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| functional near-infrared spectroscopy, fNIRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment, MoCA;Western Aphasia Battery, WAB;Boston Naming Test, BNT;Fugl-meyer motor assessment;Boxing and Blocking Test;oxy-Hb, deoxy-Hb; | — |
Countries
China
Contacts
Public ContactJie Jia
Department of rehabilitation medicine, Huashan Hospital affiliated to Fudan University
Outcome results
None listed