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Study on high dose combination therapy of amoxicillin and esomeprazole to eradicate HP infection: a randomized controlled trial.

Study on high dose combination therapy of amoxicillin and esomeprazole to eradicate HP infection

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000033759
Enrollment
Unknown
Registered
2020-06-11
Start date
2020-06-25
Completion date
Unknown
Last updated
2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori infection

Interventions

AE group:the high-dose dual therapy
AECB group:bismuth-containing quadruple scheme

Sponsors

The Second Hospital of Lanzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients who have gastroscopy in our hospital due to digestive system symptoms; 2. Patients with positive HP rut and UBT; 3. Patients who have not been treated with Helicobacter pylori eradication before; 4. Patients aged 18-70 years; 5. Patients willing to participate and able to cooperate with the study.

Exclusion criteria

Exclusion criteria: 1. Patients who took drugs that may affect the results of the study 4 weeks before admission, such as PPI, H2 receptor blocker, bismuth agent, antibiotics, etc.; 2. Patients with gastrinoma; 3. Patients after operation of stomach or esophagus; 4. Patients with serious heart, lung, kidney, liver, blood, nerve, endocrine and mental system diseases; 5. Patients who are allergic to the drugs used in this study; 6. Pregnant or nursing women; 7. Combine with other medical conditions that may increase the side effects of treatment.

Design outcomes

Primary

MeasureTime frame
Eradication rate;

Secondary

MeasureTime frame
Compliance;Safety;

Countries

China

Contacts

Public ContactJianwei Yun

The Second Hospital of Lanzhou University

yjw.2007@stu.xjtu.edu.cn+86 931-5190710

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026