major depressive disorder
Conditions
Interventions
Propofol+MECT:Propofol+MECT
MECT:MECT
MECT:MECT (8 times a course of treatment)
Esketamine+MECT:Esketamine+MECT
nonconvulsive electrotherapy:NET
Esketamine+NET:Esketamine+NET
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Sub-project one: (1) Ability to communicate and provide written consent. (2) Diagnosis of MDD or BD identified by treating psychiatrists and confirmed via a checklist of Diagnostic and Statistical Manual of Mental Disorders-4th edition (DSM-IV) criteria; TRD defined as an insufficient therapeutic response to >=2 adequate antidepressants treatment trials during the current episode. (3) Male and female patients aged 18–65 years; (4) A total score of >= 17 on the 17-item Hamilton Rating Scale for Depression (HAMD-17) at screening; (5) Participants must have junior middle school and above years of schooling; (6) Han Chinese patients, right handedness. Sub-project two: (1) Ability to communicate and provide written consent. (2) Diagnosis of MDD or BD identified by treating psychiatrists and confirmed via a checklist of Diagnostic and Statistical Manual of Mental Disorders-4th edition (DSM-IV) criteria; TRD defined as an insufficient therapeutic response to >= 2 adequate antidepressants treatment trials during the current episode. (3) Male and female patients aged 18–65 years; (4) A total score of >= 17 on the 17-item Hamilton Rating Scale for Depression (HAMD-17) at screening; (5) Participants must have junior middle school and above years of schooling; (6) Han Chinese patients, right handedness. Sub-project three: (1) Ability to communicate and provide written consent. (2) Diagnosis of MDD or BD identified by treating psychiatrists and confirmed via a checklist of Diagnostic and Statistical Manual of Mental Disorders-4th edition (DSM-IV) criteria; TRD defined as an insufficient therapeutic response to >= 2 adequate antidepressants treatment trials during the current episode. (3) Male and female patients aged 18–65 years; (4) A total score of >= 17 on the 17-item Hamilton Rating Scale for Depression (HAMD-17) at screening; (5) Participants must have junior middle school and above years of schooling; (6) Han Chinese patients, right handedness. Sub-project four: (1) Ability to communicate and provide written consent. (2) Diagnosis of MDD or BD identified by treating psychiatrists and confirmed via a checklist of Diagnostic and Statistical Manual of Mental Disorders-4th edition (DSM-IV) criteria; TRD defined as an insufficient therapeutic response to >= 2 adequate antidepressants treatment trials during the current episode. (3) Male and female patients aged 18–65 years; (4) A total score of >= 17 on the 17-item Hamilton Rating Scale for Depression (HAMD-17) at screening; (5) Participants must have junior middle school and above years of schooling; (6) Han Chinese patients, right handedness.
Exclusion criteria
Exclusion criteria: Sub-project one: (1) Other major psychiatric disorders that meet the DSM-IV diagnostic criteria include organic mental disorders, alcohol dependence, drug dependence/abuse, schizophrenia, etc; (2) Currently, there are serious and unstable somatic diseases such as diabetes, thyroid disease, hypertension, heart disease and narrow-angle glaucoma, etc; Wechsler intelligence test (WAIS-RC) full scale IQ (FIQ) total scores <= 80; (3) A history of neurological diseases such as epilepsy and dementia; (4) Subjects with metal in the body, such as pacemaker or brain electrode; (5) Previous history of anesthetics allergy; (6) Women who are at the stage of pre-pregnancy, pregnancy or lataction; (7) Contraindications to MRI or intolerant of MRI scanning environment, such as claustrophobia; (8) No MECT treatment in the past three months, the doctor in charge thinks that MECT is not suitable for treatment. Sub-project two: (1) Other major psychiatric disorders that meet the DSM-IV diagnostic criteria include organic mental disorders, alcohol dependence, drug dependence/abuse, schizophrenia, etc.; (2) Currently, there are serious and unstable somatic diseases such as diabetes, thyroid disease, hypertension, heart disease and narrow-angle glaucoma, etc; Wechsler intelligence test (WAIS-RC) full scale IQ (FIQ) total scores <= 80; (3) A history of neurological diseases such as epilepsy and dementia; (4) Subjects with metal in the body, such as pacemaker or brain electrode; (5) Previous history of anesthetics allergy (6) Women who are at the stage of pre-pregnancy, pregnancy or lataction; (7) Contraindications to MRI or intolerant of MRI scanning environment, such as claustrophobia (8) No MECT treatment in the past three months, the doctor in charge thinks that MECT is not suitable for treatment. Sub-project three: (1) Other major psychiatric disorders that meet the DSM-IV diagnostic criteria include organic mental disorders, alcohol dependence, drug dependence/abuse, schizophrenia, etc; (2) Currently, there are serious and unstable somatic diseases such as diabetes, thyroid disease, hypertension, heart disease and narrow-angle glaucoma, etc; Wechsler intelligence test (WAIS-RC) full scale IQ (FIQ) total scores <= 80; (3) A history of neurological diseases such as epilepsy and dementia; (4) Subjects with metal in the body, such as pacemaker or brain electrode; (5) Previous history of anesthetics allergy (6) Women who are at the stage of pre-pregnancy, pregnancy or lataction; (7) Contraindications to MRI or intolerant of MRI scanning environment, such as claustrophobia (8) No MECT treatment in the past three months, the doctor in charge thinks that MECT is not suitable for treatment. Sub-project four: (1) Other major psychiatric disorders that meet the DSM-IV diagnostic criteria include organic mental disorders, alcohol dependence, drug dependence/abuse, schizophrenia, etc; (2) Currently, there are serious and unstable somatic diseases such as diabetes, thyroid disease, hypertension, heart disease and narrow-angle glaucoma, etc; Wechsler intelligence test (WAIS-RC) full scale IQ (FIQ) total scores <= 80; (3) A history of neurological diseases such as epilepsy and dementia; (4) Subjects with metal in the body, such as pacemaker or brain electrode; (5) Previous history of anesthetics allergy (6) Women who are at the stage of pre-pregnancy, pregnancy or lataction; (7) Contraindications to MRI or intolerant of MRI scan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive function;Adverse effects; | — |
Countries
China
Contacts
Public ContactXiong Huang
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)
Outcome results
None listed